@article { author = {Khalifa, Marwa and Attia, Eman and Fahim, John and Kamel, Mohamed}, title = {An overview on the chemical and biological aspects of lycorine alkaloid}, journal = {Journal of advanced Biomedical and Pharmaceutical Sciences}, volume = {1}, number = {2}, pages = {41-49}, year = {2018}, publisher = {Minia University, Faculty of Pharmacy}, issn = {2535-1869}, eissn = {2535-2040}, doi = {10.21608/jabps.2018.4088.1016}, abstract = {Amaryllidaceae plants are currently appreciated as a plentiful source of unique bioactive alkaloids. Among them, lycorine is one of the major pyrrolophenanthridine alkaloids commonly isolated from different species of this family. Over the past years, lycorine has attracted great research interest owing to its superlative biological potential and pharmacological actions, including antitumor, antiangiogenic, antiviral, antibacterial, antimalarial, anti-parasite, antioxidant, hepatoprotective, analgesic, anti-inflammatory activities, and inhibition of ascorbic acid synthesis, among many others. Therefore, this review was undertaken to highlight the chemical, chromatographic, spectral, and biological aspects of this promising Amaryllidaceae alkaloid, together with a future perspective for its potential application in the pharmaceutical field.}, keywords = {Amaryllidaceae,Alkaloids,lycorine,chemical properties,biological activities}, url = {https://jabps.journals.ekb.eg/article_14975.html}, eprint = {https://jabps.journals.ekb.eg/article_14975_3687e645301567f7fcc6e687d462b236.pdf} } @article { author = {Anwar, Gehan and Farag, Fatma and Desoukey, Samar}, title = {Characterization of some garlic clones using morphological, cytological, molecular and Headspace GC/MS techniques}, journal = {Journal of advanced Biomedical and Pharmaceutical Sciences}, volume = {1}, number = {2}, pages = {50-55}, year = {2018}, publisher = {Minia University, Faculty of Pharmacy}, issn = {2535-1869}, eissn = {2535-2040}, doi = {10.21608/jabps.2018.3927.1014}, abstract = {The aim of the presented study is to identify a simple applicable method to distinguish between garlic clones that are used in pharmaceutical or food industry. Four different clones of garlic (Balady, EGA 3, EGA 4 and Growers clone) cultivated in Egypt were differentiated using morphological, cytogenetical, molecular and chemical characterization. Results of the morphological and cytogenetical characters analysis showed that there were considerable variations for all studied traits except for three; leaf width, stem diameter and chromosome numbers. Additionally, SSR (simple sequence repeats) and ISSR (inter simple sequence repeats) markers showed a high level of genetic variation among the four garlic clones. Moreover, Headspace Gas Chromatography and Mass Spectroscopy (HS GC-MS) was used for identifying and comparing the volatile constituents. The resulting peaks showed thirteen major constituents (prop-2-en-1-ol, 5-Hexenal, trans-2-trans-7-nonadiene, 1-propene,3,3`thiobis, 1-Propene, 3-(methylthio)-, disulfide,methyl-2-propenyl, camphene , disulfide, di-2-propenyl , Trisulfide, methyl-2-propenyl, Diallyltetrasulphide, 2-vinyl-[4H]-1,3-dithiin, Trisulfide, 1- Trisulfide, di-2-propenyl , 1,3Dithiane and Trisulfide, dimethyl ) were present in the four analyzed clones. The percentage of active volatile constituents in each clone could be used as chemical markers to distinguish between these clones. Accordingly, HSGS/MS is a considerably simple and fast method that can be used for initial identification of all four clones under the same conditions using the above compounds. The analysis can be performed on both entire fresh or powdered plant forms.}, keywords = {Garlic,morphological,SSR and ISSR markers,headspace sampling, Gas Chromatography and Mass Spectroscopy}, url = {https://jabps.journals.ekb.eg/article_14978.html}, eprint = {https://jabps.journals.ekb.eg/article_14978_e31190879be3ed2aedbce652820b0ea0.pdf} } @article { author = {Gomaa, Alshymaa and Samy, Mamdouh and Desoukey, Samar and Kamel, Mohamed}, title = {Phytochemistry and pharmacological activities of genus Abutilon: a review (1972-2015)}, journal = {Journal of advanced Biomedical and Pharmaceutical Sciences}, volume = {1}, number = {2}, pages = {56-74}, year = {2018}, publisher = {Minia University, Faculty of Pharmacy}, issn = {2535-1869}, eissn = {2535-2040}, doi = {10.21608/jabps.2018.3333.1000}, abstract = {Abutilon Miller is a genus belonging to family Malvaceae comprises about 150 species. The plants of this genus are annual or perennial herbs, shrubs or even small trees. It is native to the tropical and subtropical countries of America, Africa, Asia and Australia. The genus has a significant importance, which is attributed to valuable insoluble fibers obtained from different species of the genus such as Abutilon theophrastii and also due to several species grown as garden ornamental plants such as A. ochsenii and A. vitifolium. Reviewing the available literature on genus Abutilon revealed the presence of a diversity of secondary metabolites such as flavonoids, phenolic acids, sterols, triterpenes, quinones, coumarins, alkaloids, sphingolipids, megastigmanes, iridoids and others, which are responsible for its biological activities such as anti-inflammatory, analgesic, antipyretic, hepatoprotective, antioxidant, anti-hyperglycemic, gastroprotective, cytotoxic, antifungal, antibacterial, antiviral, anthelmintic, anti-malarial, anti-leishmanial, CNS activty, anti-stress, immunostimulant, anti-venom, anti-hyperlipidemic, anti-hypertensive, aphrodisiac, abortifacient, antidiarrhoeal, diuretic, anti-urolithiatic, and wound healing activities.}, keywords = {Malvaceae,Abutilon,Phytochemistry,pharmacological activities}, url = {https://jabps.journals.ekb.eg/article_14982.html}, eprint = {https://jabps.journals.ekb.eg/article_14982_1760dd3fc8057bfb4ea5a2fe65473316.pdf} } @article { author = {Abdel-Wahab, Nada and Attia, Eman and Desoukey, Samar and Elkhayat, Ehab and Fouad, Mostafa and Kamel, Mohamed}, title = {Evaluation of in vitro antioxidant activities and total phenol content of different extracts of the fungus Ulocladium chartarum isolated from Draceana leaf}, journal = {Journal of advanced Biomedical and Pharmaceutical Sciences}, volume = {1}, number = {2}, pages = {75-77}, year = {2018}, publisher = {Minia University, Faculty of Pharmacy}, issn = {2535-1869}, eissn = {2535-2040}, doi = {10.21608/jabps.2018.3589.1007}, abstract = {The objective of this study is to investigate the total phenol content and in vitro antioxidant potential of the different extracts of the fungal strain Ulocladium chartarum, isolated from Draceana leaf. The fungal culture was extracted with ethyl acetate (EtOAc) followed by methanol (MeOH). The antioxidant activities of the extracts were tested using 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) and phosphomolybdate complex assays, while total phenol content was evaluated by Folin- Ciocalteu method. The MeOH extract of Ulocladium chartarum displayed higher free radical scavenging activity (46.98% in DPPH assay) and antioxidant activity (28.86 mg ascorbic acid equivalent/g dried extract employing phosphomolybdate assay) in comparison to the EtOAc extract that displayed (11.63%) in DPPH assay and (9.5 mg ascorbic acid equivalent/g dried extract) in phosphomolybdate assay. It is noteworthy that a direct correlation between the total phenol content and the antioxidant activity was observed.}, keywords = {Antioxidant activities,total phenol content,DPPH assay}, url = {https://jabps.journals.ekb.eg/article_14983.html}, eprint = {https://jabps.journals.ekb.eg/article_14983_57c1ee351d014f4f0a230a1d5da5587d.pdf} } @article { author = {Ezelarab, Hend and Hassan, Heba and Abbas, Samar and Abd El-Baky, Rehab and Aburahama, Gamal El-Din}, title = {Design, Synthesis and Antifungal Activity of 1,2,4-Triazole/ or 1,3,4- Oxadiazole-ciprofloxacin hybrids}, journal = {Journal of advanced Biomedical and Pharmaceutical Sciences}, volume = {1}, number = {2}, pages = {78-84}, year = {2018}, publisher = {Minia University, Faculty of Pharmacy}, issn = {2535-1869}, eissn = {2535-2040}, doi = {10.21608/jabps.2018.3774.1013}, abstract = {Due to the rapid development of fungal strains resistance, there is become great demand of newer agents that can withstand these resistant strains. This study involves design and synthesis of ciprofloxacin-triazole or ciprofloxacin-oxadiazole hybrids as potential antifungal agents for the purpose of synergism. Results showed that combination of 1,2,4-triazole or its bioisoster oxadiazole with ciprofloxacin can enhance antifungal activity against Candida albicans. The triazole hybrid 11 experienced comparable antifungal activity with itroconazole (MIC = 10.23 and 11.22 µg/mL, respectively). Molecular docking study showed that hybrid 11 can bind to the active site of lanosterol 14-α-demethylase CYP51 with reasonable docking scores.}, keywords = {Fluoroquinolones,Azoles,Hybrids,Antifungal,Molecular docking}, url = {https://jabps.journals.ekb.eg/article_14985.html}, eprint = {https://jabps.journals.ekb.eg/article_14985_0a07f14ec22c38158c7c97e0d5aa905e.pdf} } @article { author = {Salem, Hesham and Omar, Mahmoud and Derayea, Sayed and Abdelaziz, Amany}, title = {Validated simultaneous TLC-spectrodensitometric method for determination of policresulen and cinchocain hydrochloride in combined dosage forms}, journal = {Journal of advanced Biomedical and Pharmaceutical Sciences}, volume = {1}, number = {2}, pages = {85-89}, year = {2018}, publisher = {Minia University, Faculty of Pharmacy}, issn = {2535-1869}, eissn = {2535-2040}, doi = {10.21608/jabps.2018.4745.1019}, abstract = {TLC-spectrodensitometric method was developed and validated for the simultaneous determination of policresulen (POL) and cinchocaine hydrochloride (CIN). The method is being separated on TLC aluminum plates coated with silica gel 60 F254, using chloroform:methanol:ammonia (9.5:0.6:1.0, v/v/v) as a mobile phase and Dragendorff reagent as spot detection at 490 nm. The linearity ranges of method were 0.8-20 and 0.2-3.5 µg band-1, for POL and CIN, respectively. The mean percentage recoveries were 100.46±1.1 and 99.65±0.49for POL and CIN, respectively. The proposed method was validated according to ICH guidelines and utilized for simultaneous determination of the cited drugs in their analytical mixtures and pharmaceutical preparations. Limits of detection were 0.23 and 0.07 µg band-1 for POL and CIN, respectively. The obtained results were statistically compared with that of the official and reported methods. Comparisons were starting to show that there is no significant difference regarding both accuracy and precision. The method was found to be precise, rapid, specific, and accurate. Thus the method can be applied for the routine analysis of POL and CIN in their pharmaceutical formulations without prior separation.}, keywords = {policresulen,cinchocain hydrochloride,TLC-spectrodensitometric,dosage forms}, url = {https://jabps.journals.ekb.eg/article_14986.html}, eprint = {https://jabps.journals.ekb.eg/article_14986_c91637791c6e6b2bf18277691f141bce.pdf} }