ORIGINAL_ARTICLE
Cubosomes: composition, preparation, and drug delivery applications.
Abstract Cubosomes can be considered as a novel lipid-based nanosystems similar to well-known vesicular systems such as liposomes and niosomes. Cubosomes have been widely formulated using certain amphiphilic lipids (e.g. glyceryl monooleate and phytantriol) in the presence of a suitable stabilizer. They can represent a novel drug delivery system which could be loaded with hydrophilic, lipophilic and amphiphilic drug molecules. They are widely used for various drug delivery applications such as oral, ocular, transdermal and chemotherapy drug delivery. In this review, the pertinent literature of cubosomes with emphasis on theories of self-assembling, the composition of cubosomes, methods of preparation and drug delivery applications will be critically reviewed.
https://jabps.journals.ekb.eg/article_54781_412e266000a903599d6b1e3f89f29696.pdf
2020-01-01
1
9
10.21608/jabps.2019.16887.1057
Cubosomes
glycerol monooleate (GMO)
phytantriol (PHYT)
Poloxamer 407
theories of self-assembling
Sherif
Gaballa
sherif_armia90@yahoo.com
1
Department of pharmaceutics, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
LEAD_AUTHOR
Omar
El Garhy
omar_elgarhy70@mu.edu.eg
2
Department of pharmaceutics, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
AUTHOR
Hamdy
Abdelkader
h.abdelkader@mu.edu.eg
3
Department of pharmaceutics, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
AUTHOR
ORIGINAL_ARTICLE
Preparation and evaluation of Ketotifen suppositories
Ketotifen KT is one of antiallergic drugs, due to its first pass effect, the bioavailability of the drug is only 50%. The objective of this study was to formulate and evaluate suppositories containing KT and/or KT solid dispersion. The in-vitro release of KT from suppositories was done using dialysis membrane method in phosphate buffer at pH 7.4. The release of KT from water soluble suppository bases was higher than that from fatty or emulsion suppositories bases. Among all PEGs bases (F4: PEG 6000: PG (20: 80)) showed a relatively higher release of KT. Formulations prepared with glycerin bases gave more or less identical release pattern; relatively formula (F17: Gelatin: Glycerin: Propylene glycol: Water) gave the highest release pattern. Formula (F20: Suppocire AM) exhibited the highest release rate among fatty bases. Within all emulsion bases (F23: W15: W75: Tween 20: Span 60: PEG 1500: Propylene glycol) showed highest release rate. KT solid dispersion led to a higher release rate of the drug from selected bases. A histological comparison between control group of rabbits (didn`t take suppository), another group took plain suppositories and group that received suppositories containing solid dispersion of KT was carried out. The tested plain and medicated bases didn’t injure the rectal mucosa of rabbits. In conclusion the incorporation of solid dispersion in formula (F4) complied with the pharmacobeial limits for hardness, dissolution time, content uniformity and weight variation. Also it showed a relatively higher in-vitro release of KT and considered as safe and useful formulation for clinical use.
https://jabps.journals.ekb.eg/article_66177_d4920e95496a7afef47ea2bc2376cc3b.pdf
2020-01-01
10
22
10.21608/jabps.2019.19318.1059
Suppository bases
Ketotifen
KT solid dispersion
In-vitro release
Histological studies
Dina
Mohamed
dina.mohamed@pharm.aun.edu.eg
1
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, 71516 Assiut, Egypt.
LEAD_AUTHOR
Omnia
Mahmoud
omnhoba2010@gmail.com
2
Department of Pharmaceutics, Faculty of Pharmacy, South Vally University, 83523 Qena, Egypt.
AUTHOR
Fergany
Mohamed
fergmed@yahoo.com
3
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, 71516 Assiut, Egypt.
AUTHOR
ORIGINAL_ARTICLE
Fast disintegrating tablets of spray dried poly-herbal extract: a promising hypoglycemic and diabetic wound healing activity.
Many herbal products have been used to control blood glucose level and minimize complications of diabetes mellitus. However, the feasibility of using such herbal product has been hindered due to the lower stability of their extracts and patients incompliance. Objective: An optimized fast disintegrating tablet preparation of spray dried aqueous extract of poly herbal blend has been formulated to maximize the therapeutic activity of such herbal extract. Methods: different ratios of superdisintegrants were evaluated in terms of reducing disintegration time and wetting time of the prepared formulations. The potential of the optimized formula in reducing blood glucose level and promoting wound healing in STZ-induced diabetic rats was determined. Key finding: Oral administration of the optimized formula (F6) had significant superior effect in reducing blood glucose level and promoting wound healing of diabetic rats compared receiving the aqueous extract of the herbal blend (P<0.05, p<0.01, respectively). That may be attributed to the enhanced stability and the accurate dosing of such solid dosage form. In addition, no remarkable toxic manifestations or histologic changes were observed in treated animals. Conclusion: These findings uncover the potential of the formulated dosage form in enhancing the hypoglycemic and wound healing activity of the herbal extract.
https://jabps.journals.ekb.eg/article_66186_565aadd53091e682e4d87413223d33c9.pdf
2020-01-01
23
30
10.21608/jabps.2019.19840.1060
Fast disintegrating tablets
herbal blend
spray dried
hypoglycemic
Wound healing
Mohamed
Mahran
mahranman3@gmail.com
1
Department of Pharmaceutics, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.
AUTHOR
Omar
elgarhy
omarelgarhy70@yahoo.com
2
Department of Pharmaceutics, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.
AUTHOR
Amal
Hussein
amal_ka@yahoo.com
3
Department of Pharmaceutics, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.
AUTHOR
Al-Shaimaa
Ahmed
shffa@outlook.com
4
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.
AUTHOR
Mohamed
Taha
mohamedsharawe@yahoo.com
5
Department of Internal Medicine and Nephrology, Faculty of Medicine, Minia University, 61519 Minia, Egypt.
AUTHOR
Eman
Alaaeldin
eman_alaa_eldin@yahoo.com
6
Department of Pharmaceutics, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.
LEAD_AUTHOR
ORIGINAL_ARTICLE
Amelioration of Sepsis-Induced Liver and Lung Injury by a Superoxide Dismutase Mimetic; Role of TNF-α and Caspase-3
Oxidative stress plays an important role in the development of sepsis and its associated serious consequence leading to multiple organ failure and death. Since the liver and the lungs are among the early affected organs responsible for the mortality in sepsis, we investigated the effect of Tempol, a superoxide dismutase mimetic agent, on lung and liver injuries in a cecal ligation and puncture (CLP)-induced sepsis. Septic animals were given Tempol either before or after CLP procedure. Sepsis outcomes were assessed mainly on the liver and lungs. Separate animal groups were employed for a survival study. CLP resulted in 0% survival, while Tempol pre-or post-treatment led to a 100% and 40% survival, respectively. Administration of Tempol resulted in a significant attenuation of sepsis-induced elevation of lipid peroxidation. In the lungs and liver tissues, Tempol resulted in a significant attenuation of elevated tumor necrosis factor-α and caspase-3. Histopathological examination of the lungs and liver confirmed the protective effects of Tempol on these organs. In conclusion: Tempol acts as both prophylactic and therapeutic agent in a rat sepsis model by lowering oxidative stress, inflammatory and apoptotic signals induced by sepsis and reducing lung and liver damage induced by sepsis.
https://jabps.journals.ekb.eg/article_66194_1a0de33fe96921fb0947cab668a37243.pdf
2020-01-01
31
39
10.21608/jabps.2019.19876.1061
CLP, NO scavenger
Caspase-3
TNF-α
Al-Shaimaa
Ahmed
shffa@outlook.com
1
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.
LEAD_AUTHOR
Asmaa
Bayoumi
asmaa_bayoumi@mu.edu.eg
2
Department of Biochemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.
AUTHOR
Heba
Eltahir
heba_m.eltahir@yahoo.com
3
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Taibah University, Saudi Arabia.
AUTHOR
Sara
Abdel Hafez
sara_histology@yahoo.com
4
Department of Histology and Cell Biology, Faculty of Medicine, Minia University, 61519 Minia, Egypt.
AUTHOR
Mekky
Abouzied
m_meky2001@yahoo.com
5
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Taibah University, Saudi Arabia.
AUTHOR
ORIGINAL_ARTICLE
Survey the Genetic Diversity of Eight Opuntia Species from Egypt using Random Amplified Polymorphic DNA (RAPD) Technique
Opuntia is a large genus of succulent shrubs characterized by unique attractive flowers known as prickly pears by virtue of their characteristic edible fruits. They are used as laxative, diuretic, antipyretic, and anti-inflammatory. This study aims to authenticate eight different Opuntia species, Opuntia brasilliensis (Willd.) Haw (O1), Opuntia dillenii (ker Gawl.) Haw. (O2), Opuntia dejecta Salm-Dyck (O3), Opuntia ficus indica (L.) Mill. (O4), Opuntia tomentosa Salm-Dyck (O5), Opuntia phaecantha Engelm. (O6), Opuntia leucotricha DC. (O7), Opuntia microdasys (Lehm.) Pleiff. (O8), growing in Egypt by using random amplified polymorphic DNA technique. Accurate identification of the eight Opuntia species is an urgent need to maintain herbal formulations potency and peculiarity. Similarity coefficients of 40.0 - 67.6% classified Opuntia species into two main groups, one of them contains two species and the other one contains six species. Consequently, this technique helps the identification of these Opuntia species showing great morphological similarity.
https://jabps.journals.ekb.eg/article_65940_caa8db59dfb1c2377f57111e71bfe917.pdf
2020-01-01
40
44
10.21608/jabps.2019.20728.1062
RAPD
Genetic diversity
DNA fingerprinting
Opuntia
Cactaceae
Mohamed
Rabeh
mohamedabdelatty68@yahoo.com
1
Department of Pharmacognosy, Faculty of pharmacy, Cairo University, Cairo 11562, Egypt.
LEAD_AUTHOR
Seham
El-Hawary
seham.elhawary@yahoo.com
2
Department of Pharmacognosy, Faculty of pharmacy, Cairo University, Cairo 11562, Egypt.o, Egypt
AUTHOR
Mona
El-Tantawy
kader48@hotmail.com
3
Department of Medicinal plants and natural products, National Organization of Drug Control and Research, Giza, Egypt.
AUTHOR
Usama
Abdelmohsen
usama.ramadan@mu.edu.eg
4
Department of Pharmacognosy, faculty of Pharmacy, Minia University, 61519 Minia, Egypt
AUTHOR
Wafaa
Badr
wafaakorany@ymail.com
5
Department of Medicinal plants and natural products, National Organization of Drug Control and Research, Giza, Egypt.
AUTHOR