2024-03-29T13:36:56Z
https://jabps.journals.ekb.eg/?_action=export&rf=summon&issue=7864
Journal of advanced Biomedical and Pharmaceutical Sciences
2535-1869
2535-1869
2019
2
4
Natural polyphenols target the TGF-β/caspase-3 signaling pathway in CCl4-induced liver fibrosis in rats
Rania
Abu-Baih
Asmaa
Bayoumi
Ahmed
Ibrahim
Mohamed
Ewees
Salama
Abdelraheim
Background/Aims: Liver fibrosis presents a worldwide problem. There is an increasing interest in the studying of natural compounds with free radicals scavenging capacity to protect against liver fibrosis. This study investigated the actions of resveratrol and curcumin as two natural polyphenols against CCl4-induced liver fibrosis. Materials and Methods: Animals were divided into four groups: Normal control group; CCl4 only group; Res group (resveratrol + CCl4); Cur group (curcumin + CCl4). Serum ALT and AST were evaluated. Assessment of liver MDA, GSH and catalase was performed. Caspase-3 expression was evaluated by western blotting. Levels of TGF-β1 and TGF-β2 mRNA were determined using qRT-PCR. In addition, liver histopathological sections were examined. Results: We found that serum ALT and AST were elevated by CCl4, however, they were significantly reduced by resveratrol and curcumin. Furthermore, CCl4 induced oxidative stress, stimulated fibrosis and apoptosis. Resveratrol and curcumin significantly attenuated the state of oxidative stress, fibrosis and apoptosis. Conclusion: We conclude that resveratrol and curcumin are natural polyphenols that can protect against liver fibrosis not only via antioxidant, but also via anti-fibrotic and anti-apoptotic potentials.
Liver fibrosis
Resveratrol
Curcumin
TFG-β
Caspase-3
2019
10
01
129
134
https://jabps.journals.ekb.eg/article_41439_50a2fc09797cea2d8974dc22980d6a11.pdf
Journal of advanced Biomedical and Pharmaceutical Sciences
2535-1869
2535-1869
2019
2
4
Recent Prospectives of Anticancer Histone Deacetylase Inhibitors
Shymaa
Abbass
Heba
Hassan
Mamdouh
Mohamed
Gamal
Moustafa
Gamal
Abuo-Rahma
Histone deacetylases (HDACs) are common targets for cancer therapy as they are expressed in many forms of cancers; several research studies have been introduced discussing the design of small molecules that target this abnormal epigenetic changes developed by HDACs in chromatin. In the past 10 years, HDAC inhibitors have emerged as important agents of interest in clinical trials for several types of cancers and other diseases. Due to the recent availability of a number of HDACIs into market as effective anticancer agents (like vorinostat, belinostat, panobinostat, romidepsin, chidamide and pracinostat), HDACIs are considered one of the promising targeted anticancer agents. The current review highlights the most recent chemical modifications of HDACIs including different caps, linkers and zinc binding groups and interestingly the dual acting or multi-targeted HDACIs.
Anticancer
HDACIs
Hydroxamic acids
Multi-targeted HDACIs
2019
10
01
135
151
https://jabps.journals.ekb.eg/article_44190_4620aad0866242cfdbfaedc7069a739c.pdf
Journal of advanced Biomedical and Pharmaceutical Sciences
2535-1869
2535-1869
2019
2
4
Different Approaches for Enhancement of Curcumin Aqueous Solubility and Dissolution rate
Abeer
Hassan
Mona
EL-Mahdy
Mahmoud
EL-Badry
Gamal
EL-Gindy
Curcumin (CUR) is a nature polyphenolic phytoingredient. CUR showed anti-inflammatory, anti-oxidant, anti-fungal and anti-cancer activities. The therapeutic efficacy of CUR was limited due to its poor aqueous solubility, poor oral bioavailability. Poor solubility of drugs is the major challenge associated with formulation development. Therefore, the aim of present work was to enhance CUR aqueous solubility and dissolution rate using Physical mixture and its solid dispersion. CUR solid dispersions were prepared by solvent evaporation and Freeze drying techniques using different polymers, such as cyclodextrins, polyvinyl pyrrolidone (PVP K30), polyethylene glycol 6000 and Pluronic®F-127. The prepared physical mixtures, solid dispersions were characterized using different techniques such as (DSC), (FTIR) and (XRD). Furthermore, the solubility and the dissolution rate of the drug in its different systems were explored. The results of physical characterization of the different systems show no interaction between them. Dissolution studies of CUR solid dispersions showed that the highest drug dissolution rate was achieved at CUR/ Pluronic®F-127 weight ratio of 1:3. Also, complete drug dissolution was obtained for CUR/Pluronic F-127 solid dispersion after 30 min compared to 35% dissolution for CUR alone after the same time. Also, CUR permeability coefficient through rat skin for Pluronic®F-127 micelles and solid dispersion were two times higher than that of the CUR alone. The obtained results concluded that, the preparation of solid dispersion of Pluronic®F-127 solid dispersions by freeze drying method is a promising one to overcome CUR shortcomings through enhancing its aqueous solubility, dissolution rate and skin permeability.
Curcumin
Freeze drying
Solid dispersions
Solubility
dissolution rate
2019
10
01
152
163
https://jabps.journals.ekb.eg/article_48115_3ecdc5e6acb2fc78e4d578fd2c7ffa4d.pdf
Journal of advanced Biomedical and Pharmaceutical Sciences
2535-1869
2535-1869
2019
2
4
Colon Drug Delivery Systems for the Treatment of Inflammatory Bowel Disease.
Milad
Qelliny
Omar
Elgarhy
Khaled
Khaled
Usama
Aly
Inflammatory bowel disease (IBD) is one of the most common chronic diseases that affect the entire gastrointestinal tract (GIT) especially the colon. Its symptoms extend from mild diarrhea, abdominal pain, and bloody diarrhea to severe conditions which affect the quality of life. Many treatments have been developed to treat and cure IBD and to improve patient’s quality of life. The big challenge faces the newly developed treatments is the site of action as the colon presents at the distal end of the GIT and have a complex biological environment. Many technologies have been investigated to target the colon, load higher amounts of active ingredients, and decrease unwanted side effects resulted from upper GIT absorption. This review briefly discusses the IBD, treatment lines, physiological considerations, and all methods of colon targeting technologies starting from the traditional methods which based on pH, time, and microbial content of the colon. Also, we discussed in detail all new techniques based on Micro and Nanotechnology which improve the effectiveness of used therapeutics.
inflammatory bowel disease
colon drug delivery systems
OROS-CT
pH-dependent carriers
novel colon approaches
2019
10
01
164
184
https://jabps.journals.ekb.eg/article_50287_39fef58936207dfa31ee92ab270f715e.pdf
Journal of advanced Biomedical and Pharmaceutical Sciences
2535-1869
2535-1869
2019
2
4
Synthesized oxime and ketone derivatives of ibuprofen have higher hepatic safety profile and hepatoprotective potential against acute CCl4 - induced hepatotoxicity in rats
Hend
Abd-Elhakam
Thoraya
El-Deeb
Heba
Abd-Ellah
Mai
Shoman
Eman
Beshr
Mohamed
Abdel-Aziz
Maiiada
Nazmy
Despite previously reported high hepatic safety profile of ibuprofen (IBP), but other reports oppose its use in hepatic patients. The aim of this study is to evaluate the possible effect of IBP besides its oxime (OI) and ketone (KI) derivatives in both normal liver and in acute CCl4-induced hepatotoxicity. Sixty adult male Wistar rats were used, divided into 8 groups. Group 1: received saline water as normal control. Groups 2,3,4: treated with IBP, OI or KI respectively. Group 5: treated with CCl4 to induce hepatotoxicity. Groups 6,7,8: treated with IBP, OI or KI respectively 30 minutes before CCl4 administration. Current results showed that despite the apparent hepatotoxic effects of IBP, which were less evident in OI and KI, on normal liver that may be explained by possible immunological idiosyncrasy, they ameliorated both hepatocellular and cholestatic damage induced by CCl4, which may be attributed to their anti-inflammatory and anti-oxidant potential. OI and KI derivatives, rather than IBP, showed higher hepatic safety profile and stronger hepatoprotective potential against acute CCl4-induced hepatotoxicity, which favor their use, instead of IBP, in concurrent hepatic diseases.
Ibuprofen
Oxime
Ketone
Carbon tetrachloride
Hepatotoxicity
2019
10
01
185
190
https://jabps.journals.ekb.eg/article_50537_a2ec016daabfff33d69c4e56c24dc3d8.pdf