Minia University, Faculty of PharmacyJournal of advanced Biomedical and Pharmaceutical Sciences2535-18692120190101Interleukin-27 and Risk of Coronary Artery Disease162308910.21608/jabps.2018.5020.1020ENMohamed Abu KheshaKamelMolecular Biology center, Faculty of pharmacy, Minia university ,MiniaAhmed RagaaNour IbrahimDepartment of Biochemistry, Faculty of Pharmacy, Minia University, 61519 Minia, EgyptGamal El-DinAbu RahmaDepartment of Medicinal chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, EgyptJournal Article20180903Cardiovascular diseases (CVDs) are the most abundant causative factors of mortality and morbidity in the world specifically in the developing countries. Many studies on humans and animals prove that inflammation plays a key role in the initiation and propagation of the process of atherosclerosis. Interleukin-27 (IL-27) is a new IL-12/IL-6 family member which is a heterodimeric multifunctional pro- and anti-inflammatory cytokine. IL-27 one of the important cytokines distinguished in atherosclerotic plaques. In this review, we demonstrate the coronary artery disease and its pathogenesis, the role of inflammation in the initiation and progression of atherosclerosis, IL-27, IL-27 receptors and signaling pathway, pro and anti-inflammatory characters of IL-27 and finally the effect of IL-27 as an inflammatory mediator in the process of atherogenesis.Minia University, Faculty of PharmacyJournal of advanced Biomedical and Pharmaceutical Sciences2535-18692120190101Treatment with NaHS reduces systolic blood pressure and ameliorates oxidative stress in DOCA-Salt hypertensive rats7112309210.21608/jabps.2018.5154.1021ENAmr A.KamelDepartment of Pharmacology & Toxicology, Faculty of Pharmacy, Minia University, 61519 Minia, EgyptAshraf TayeDepartment of Pharmacology & Toxicology, Faculty of Pharmacy, Minia University, 61519 Minia, EgyptDepartment of Pharmacology & Toxicology, Faculty of Pharmacy, South Valley University, Qena, EgyptMontaser M. A.KhalifaDepartment of Pharmacology & Toxicology, Faculty of Pharmacy, Minia University, 61519 Minia, EgyptJournal Article20180916Background: Hypertension is one of the most serious cardiovascular diseases due to its end organ complications on the heart, kidney, and brain. Hydrogen sulfide gas was shown to be synthesized in vivo and it was found to play multiple physiologic and pathophysiologic roles on different organ systems; However, its role in regulation of blood pressure is not well-understood; Thus, the aim of this study is to investigate the effects of the H2S donor, NaHS on systolic blood pressure and oxidative stress in a chronic model of hypertension. Materials and methods: Hypertension was induced by in male Sprague Dawley rats by unilateral nephrectomy followed by injection of deoxycorticosterone acetate (DOCA) (20 mg/kg) in olive oil s.c. twice weekly for 4 weeks in addition; drinking water was replaced by 1 % NaCl solution. Briefly animals were divided into three groups, 4 animals of each; sham control, hypertensive non-treated (HTN) and hypertensive treated with NaHS (HTN-NaHS) 56 μmole/kg/day in normal saline, i.p for 4 weeks. Blood pressure was measured by a non-invasive tail cuff method before induction of hypertension, after induction and after treatment with NaHS. At the end of experiment blood and aortic tissue samples were collected for assessment of malondialdehyde (MDA) and catalase enzyme activity. Results: Treatment with NaHS caused significant decrease in systolic blood pressure, decrease of MDA level in serum and aortic tissue and increase of catalase enzyme activity in aortic tissue. Conclusion: NaHS treatment reduced blood pressure and ameliorated oxidative stress in hypertensive rats.Minia University, Faculty of PharmacyJournal of advanced Biomedical and Pharmaceutical Sciences2535-18692120190101Resveratrol protects against early cardiomyopathic changes-induced by Type-1 diabetes through a heme-oxygenase-1 dependent mechanism12182309310.21608/jabps.2018.5175.1022ENAsmaa S.A.HammadDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, 61519 Minia, EgyptAl-Shaimaa F.AhmedDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt0000-0001-9875-639Gehan H.HeebaDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, 61519 Minia, EgyptAshraf A.TayeDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, 61519 Minia, EgyptDepartment of Pharmacology & Toxicology, Faculty of Pharmacy, South Valley University, Qena, EgyptJournal Article20180918Diabetes can be considered as a state of chronic inflammation and oxidative stress. Excessive oxidative stress is implicated in the pathogenesis of all diabetic complications. Heme oxygenase-1 is an antioxidant enzyme that is upregulated in response to a variety of insults as a protective mechanism. Resveratrol (RSV) is a polyphenol that exhibits promising pharmacological effects in a variety of disease models. In this study, we investigated the role of RSV in prevention of early pathological changes in the diabetic heart as well as the role of hemeoxygenase-1 in this regard. To achieve this aim, diabetes was induced by ip injection of streptozotocin (50 mg/kg). The rats were divided into 5 experimental groups; normal control (CTR), diabetic control (DM), diabetic rats treated with RSV (DM+RSV); 10 mg/kg) in drinking water, diabetic rats treated with a combination of RSV and an HO-1 inhibitor, Zinc protoporphyrin (ZnPP), (DM + RSV+ZnPP); 10 µmole/Kg/week I.P) and diabetic rats treated with ZnPP alone (DM + ZnPP). Induction of diabetes was accompanied by a significant increase in cardiac MDA level and TGF-β protein expression as well as a significant reduction in eNOS and HO-1 expression. Chronic treatment with RSV significantly attenuated the abovementioned biochemical changes associated with diabetes in addition to alleviation of diabetes-induced histopathological alterations. Furthermore, the effect of RSV was diminished when the HO-1 activity was blocked by ZnPP. These results demonstrate the role of HO-1 in mediating RSV protective effects against diabetes-induced early cardiomyopathy.Minia University, Faculty of PharmacyJournal of advanced Biomedical and Pharmaceutical Sciences2535-18692120190101Pyridazinones and pyrrolones as promising Scaffolds in Medicinal Chemistry19282309410.21608/jabps.2018.5283.1023ENMahmoud SAbdelbasetDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, 71524 Assiut, EgyptMohamed Abdel-AzizDepartment of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, EgyptGamal El-Din AAbuo-RahmaDepartment of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, EgyptMohammed RamadanDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, 71524 Assiut, EgyptMostafa HAbdelrahmanDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, 71524 Assiut, EgyptJournal Article20180926Pyridazinones and pyrrolones are important building blocks for some important drugs such as the naturally occurring antibacterial pyrrolone, althiomycin; the cardiotonic pyridazinones, pimobendan and levosimendan and the analgesic anti-inflammatory, emorfozan. Therefore, researchers all over the world paid attention to prepare various pyridazinones and pyrroolones derivatives. The variability in the biological response and ease of preparation from the corresponding furanones attracted attention of researchers to explore these two nuclei in the design and synthesis of different analogues with potential biological actvities. This review article focuses on different biological activities, structure activity relationship and mechanism of action of pyridazinones and pyrrolones derivatives.Minia University, Faculty of PharmacyJournal of advanced Biomedical and Pharmaceutical Sciences2535-18692120190101A comprehensive review of phytoconstituents and biological activities of genus Zinnia29372309510.21608/jabps.2018.5599.1024ENAlshymaa Abdel-RahmanGomaaDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, EgyptMamdouh NabilSamyDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, EgyptSamar YehiaDesoukeyDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt0000-0002-4462-9674Mohamed KamelDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, EgyptDepartment of Pharmacognosy, Faculty of Pharmacy, Deraya University, 61111 New Minia, EgyptJournal Article20181014Zinnia genus contains annual and perennial plants belonging to family Asteraceae and comprising about 20 species native to South America. Zinnia species are used in folk medicine for the treatment of malaria and stomach pain and are used as hepatoprotective, antiparasitic, antifungal and antibacterial agents. Zinnia plants are well known ornamental plants with large, beautiful and attractive flowers. This review is first attempt for assembling the published papers about the isolated phytochemical components and pharmacological actions of this genus. Many studies reported that Zinnia contains numerous secondary metabolites of different classes including sterols, flavonoids, sesquiterpenes, diterpenes and hydrocarbons. Zinnia plants also are reported to possess a wide range of biological effects such as antioxidant, hepatoprotective, cytotoxic, antibacterial, antifungal and insecticidal activities. This review potentiates the researchers for carrying out further studies on this genus to isolate and develop new drugs from natural sources with wide margin of safety and understanding their effects and possible mechanism of actions.Minia University, Faculty of PharmacyJournal of advanced Biomedical and Pharmaceutical Sciences2535-18692120190101Quantitative Analysis of Total Phenolic and Total Flavonoid Constituents of some Ficus species38402309610.21608/jabps.2018.5945.1027ENHeba A.HassanDepartment of Pharmacognosy, Faculty of Pharmacy, Deraya University, 61111 New Minia, EgyptEman ZekryAttiaDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, EgyptSamar Y.DesoukeyDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt0000-0002-4462-9674Khaled M.MohamedDepartment of Pharmacognosy, Faculty of Pharmacy, Assiut University, 71526 Assiut, EgyptMohamed S.KamelDepartment of Pharmacognosy, Faculty of Pharmacy, Deraya University, 61111 New Minia, EgyptDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, EgyptJournal Article20181029The study was designed to compare the total phenolic and flavonoid contents of the total methanolic extracts of seven Ficus species (F. bengalensis, F. decora, F. hawaii, F. virens, F. platyphylla, F. retusa, and F. cycomorous) cultivated in Egypt. Leaves of the different Ficus species were each separately extracted with methanol, and dried under vacuum to give a syrupy consistency. All dried extracts showed a wide variation of total phenolic contents when tested by Folin–Ciocalteu method ranging from 2.507±0.715 to 7.9744±0.565mg gallic acid equivalent/g dried extract. Total flavonoid contents were evaluated using modified Aluminum chloride colourimetric method. The results were ranged from 1.8571±0.658 to 12.4643±0.366 mg rutin equivalent/g dried extract. Results of various assays were analyzed statistically by applying appropriate statistical methods.