Fouad, M., Zidan, S., Orabi, M., Abdelhamid, R., Allian, A., matsunmai, K. (2021). Cytotoxicity and anti-leishmanial activity of the Red Sea soft coral Sarcophyton spongiosum. Journal of Advanced Biomedical and Pharmaceutical Sciences, 4(2), 107-110. doi: 10.21608/jabps.2021.62964.1120
Mostafa A. Fouad; sabry Zidan; Mohamed A. A. Orabi; Reda A. Abdelhamid; Abdallah Allian; katsuyoshi matsunmai. "Cytotoxicity and anti-leishmanial activity of the Red Sea soft coral Sarcophyton spongiosum". Journal of Advanced Biomedical and Pharmaceutical Sciences, 4, 2, 2021, 107-110. doi: 10.21608/jabps.2021.62964.1120
Fouad, M., Zidan, S., Orabi, M., Abdelhamid, R., Allian, A., matsunmai, K. (2021). 'Cytotoxicity and anti-leishmanial activity of the Red Sea soft coral Sarcophyton spongiosum', Journal of Advanced Biomedical and Pharmaceutical Sciences, 4(2), pp. 107-110. doi: 10.21608/jabps.2021.62964.1120
Fouad, M., Zidan, S., Orabi, M., Abdelhamid, R., Allian, A., matsunmai, K. Cytotoxicity and anti-leishmanial activity of the Red Sea soft coral Sarcophyton spongiosum. Journal of Advanced Biomedical and Pharmaceutical Sciences, 2021; 4(2): 107-110. doi: 10.21608/jabps.2021.62964.1120
Cytotoxicity and anti-leishmanial activity of the Red Sea soft coral Sarcophyton spongiosum
1Pharmacognosy Department, faculty of Pharmacy, Minia University, Minia 61519, Egypt
2Departement of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt
3Departement of Zoolgy, Faculty of Science, Al-Azhar University, Assiut Branch, Assiut, Egypt
4Departement of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8553, Japan
Abstract
The aim of the present study is the evaluation of the in-vitro cytotoxicity and antileishmanial activities of a methanolic extract and its different fractions of the soft coral Sarcophyton spongiosum collected from the Egyptian Red Sea against three cancer cell lines, A549, HepG2, and MCF-7, and a protozoan, Leishmania Major, by the MTT assay protocol. The dichloromethane fraction exhibited significant anti-Leishmania major (IC50 28.1 ± 1.2 µg/mL) and cytotoxic activities against MCF-7 cell line IC50 (31.5 ± 1.1 µg/mL). The ethyl acetate fraction showed promising cytotoxicity against A549 and HepG2 cell lines (IC50 13.4 ± 1.2 and 11.6 ± 1.9 µg/mL, respectively). A preliminary chemical screening of the total methanolic extract indicated of the presence of sterols and diterpenes.
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