Role of vitamin D and insulin resistance in polycystic ovary syndrome

Abdallah, Aya Mohammed; Elazab, Gamal; Mosbeh, Mohammed Hani; Sarhan, Hatem

doi:10.21608/jabps.2021.70702.1125

Role of vitamin D and insulin resistance in polycystic ovary syndrome

Document Type : Review Articles

Authors

¹ faculty of pharmacy minia university

² clinical pharmacy department, faculty of pharmacy, Tanta university

³ Obstetrics and Gynaecology department, Faculty of Medicine, Minia University

⁴ Pharmaceutics Department, Faculty of Pharmacy, Minia University, Minia, Egypt

10.21608/jabps.2021.70702.1125

Abstract

Polycystic ovary syndrome (PCOS) is considered the commonest endocrinological disorder in childbearing age women with an incidence of 10%. Vitamin D has been shown in several studies to have a positive impact on female reproductive diseases, as well as PCOS. The diagnosis of PCOS, clinical symptoms, pathophysiology, hypovitaminosis D, insulin resistance, and the various methods for vitamin D and insulin assessment are all covered in this study. Androgen hypersecretion, oligo-ovulation, and/or ovarian morphologic features are used to diagnose this condition. Androgen excess, neuroendocrine causes, and insulin resistance are all part of the pathophysiology. Some female genital organs have been found to contain vitamin D receptors. Insulin regulates steroid biosynthesis in the ovaries and follicular maturation, so vitamin D is essential.

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