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kamel, M., Nour Ibrahim, A., Abu Rahma, G. (2019). Interleukin-27 and Risk of Coronary Artery Disease. Journal of Advanced Biomedical and Pharmaceutical Sciences, 2(1), 1-6. doi: 10.21608/jabps.2018.5020.1020
Mohamed Abu Khesha kamel; Ahmed Ragaa Nour Ibrahim; Gamal El-Din Abu Rahma. "Interleukin-27 and Risk of Coronary Artery Disease". Journal of Advanced Biomedical and Pharmaceutical Sciences, 2, 1, 2019, 1-6. doi: 10.21608/jabps.2018.5020.1020
kamel, M., Nour Ibrahim, A., Abu Rahma, G. (2019). 'Interleukin-27 and Risk of Coronary Artery Disease', Journal of Advanced Biomedical and Pharmaceutical Sciences, 2(1), pp. 1-6. doi: 10.21608/jabps.2018.5020.1020
kamel, M., Nour Ibrahim, A., Abu Rahma, G. Interleukin-27 and Risk of Coronary Artery Disease. Journal of Advanced Biomedical and Pharmaceutical Sciences, 2019; 2(1): 1-6. doi: 10.21608/jabps.2018.5020.1020

Interleukin-27 and Risk of Coronary Artery Disease

Article 1, Volume 2, Issue 1, January 2019, Page 1-6  XML PDF (565.29 K)
Document Type: Review Articles
DOI: 10.21608/jabps.2018.5020.1020
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Authors
Mohamed Abu Khesha kamel1; Ahmed Ragaa Nour Ibrahim email 2; Gamal El-Din Abu Rahma3
1Molecular Biology center, Faculty of pharmacy, Minia university ,Minia
2Department of Biochemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
3Department of Medicinal chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
Abstract
Cardiovascular diseases (CVDs) are the most abundant causative factors of mortality and morbidity in the world specifically in the developing countries. Many studies on humans and animals prove that inflammation plays a key role in the initiation and propagation of the process of atherosclerosis. Interleukin-27 (IL-27) is a new IL-12/IL-6 family member which is a heterodimeric multifunctional pro- and anti-inflammatory cytokine. IL-27 one of the important cytokines distinguished in atherosclerotic plaques. In this review, we demonstrate the coronary artery disease and its pathogenesis, the role of inflammation in the initiation and progression of atherosclerosis, IL-27, IL-27 receptors and signaling pathway, pro and anti-inflammatory characters of IL-27 and finally the effect of IL-27 as an inflammatory mediator in the process of atherogenesis.
Keywords
Interleukin-27; Coronary Artery Disease; cardiovascular diseases; Inflammation; interleukin
Main Subjects
Biochemistry
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