Animal models of pulmonary hypertension; going beyond classical models of induction

Zeidan, Esraa; Khalifa, Montaser Abdulhakim; Taye, Ashraf

doi:10.21608/jabps.2022.148245.1160

Animal models of pulmonary hypertension; going beyond classical models of induction

Document Type : Review Articles

Authors

¹ Department of pharmacology and toxicology, faculty of pharmacy, Minia University, El-Minia, Egypt.

² Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University

³ Pharmacology and Toxicology Department, Faculty of Pharmacy, South Valley University, South Valley, Egypt.

10.21608/jabps.2022.148245.1160

Abstract

Pulmonary hypertension (PH) is a life threatening pulmonary vascular disease, characterized by elevated pulmonary arterial pressure (PAP), pulmonary vascular remodeling and right sided heart hypertrophy. Due to the emergence of right ventricular (RV) failure, PH, in spite of recent therapeutic improvements, continues to be a fatal condition. Although there are already many animal models of pulmonary hypertension accessible in research, improvement in RV function and effective remodeling reversal remain a therapeutic challenge. The right utilization of traditional and novel PH animal models is crucial for understanding the underlying pathological mechanisms to reverse severe phenomenon. This review gives a general summary of the various models for PH induction, along with each method's benefits and drawbacks.

Keywords