Promising Antidiabetic and Wound Healing Activities of Forsskaolea tenacissima L. Aerial Parts.

Assaf, Hamdy K.; Nafady, Alaa M.; Allam, Ahmed E.; Hamed, Ashraf N. E.; Kamel, Mohamed S.

doi:10.21608/jabps.2019.7542.1034

Promising Antidiabetic and Wound Healing Activities of Forsskaolea tenacissima L. Aerial Parts.

Document Type : Original Article

Authors

¹ Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, 71524 Assiut, Egypt

² Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

³ Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, 61111 New Minia, Egypt

10.21608/jabps.2019.7542.1034

Abstract

The aim of present study was to evaluate antidiabetic activity of the total methanolic extract (TME) and different fractions of Forsskaolea tenacissima L. aerial parts with alloxan induced diabetic rats and evaluate wound healing activity with excision wound model in rats as well as determination of toxicological activity by lethal dose 50% (LD50). The ethyl acetate fraction showed a significant decrease in blood glucose level (36.00%, P<0.001) in comparison with glibenclamide (36.14%, P<0.001) as standard. The TME group showed marked increase in wound healing activity (97.9%, P<0.001) compared with Garamycin® ointment standard group (96.8%, P<0.001). The TME is safe due to the LD50 was 7 g/kg body weight.

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