Abdelaziz, M., Abou-Zied, H., Beshr, E., Hayallah, A. (2023). Chalcone Scaffold: A masterpiece for medicinal chemistry recent biological insights. Journal of Advanced Biomedical and Pharmaceutical Sciences, 6(2), 90-96. doi: 10.21608/jabps.2023.184496.1177
Mohamed Abdelaziz; Hesham A. Abou-Zied; Eman A Beshr; Alaa M. Hayallah. "Chalcone Scaffold: A masterpiece for medicinal chemistry recent biological insights". Journal of Advanced Biomedical and Pharmaceutical Sciences, 6, 2, 2023, 90-96. doi: 10.21608/jabps.2023.184496.1177
Abdelaziz, M., Abou-Zied, H., Beshr, E., Hayallah, A. (2023). 'Chalcone Scaffold: A masterpiece for medicinal chemistry recent biological insights', Journal of Advanced Biomedical and Pharmaceutical Sciences, 6(2), pp. 90-96. doi: 10.21608/jabps.2023.184496.1177
Abdelaziz, M., Abou-Zied, H., Beshr, E., Hayallah, A. Chalcone Scaffold: A masterpiece for medicinal chemistry recent biological insights. Journal of Advanced Biomedical and Pharmaceutical Sciences, 2023; 6(2): 90-96. doi: 10.21608/jabps.2023.184496.1177
Chalcone Scaffold: A masterpiece for medicinal chemistry recent biological insights
1Faculty of Pharmacy, Minia University, Minia Egypt
2Medicinal Chemistry Department, Faculty of Pharmacy, Deraya University, Minia, Egypt.
3Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia-61519, Egypt
4Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University
Abstract
In medicinal chemistry, privileged structures are frequently used as an effective template for finding new drugs. Chalcone is a typical simple sugar that occurs in a wide variety of naturally occurring compounds. Chalcone derivatives are also prepared in large quantities due to their simple synthesis. These organic substances and synthetic ones have demonstrated a wide range of intriguing biological behaviors with therapeutic potential for treating several diseases. This review aims to draw attention to recent research that shows chalcone to be a preferred solvent in medicinal chemistry. The primary goals of this review are to provide comprehensive information on chalcone-based hybrids, discuss recent advancements in the chemistry of chalcones with their diverse bioactive implications for the eradication of disease, and develop novel hybrids with desirable therapeutic mechanisms.
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