Elshamsy, A., Ali, T., Osman, M., El-Koussi, N. (2023). Recent progress in biological activities of dihydropyrimidine derivatives: An updated mini-review. Journal of Advanced Biomedical and Pharmaceutical Sciences, 6(3), 114-123. doi: 10.21608/jabps.2023.198467.1183
Ali M. Elshamsy; Taha F. S. Ali; Mohamed Osman; Nawal A. El-Koussi. "Recent progress in biological activities of dihydropyrimidine derivatives: An updated mini-review". Journal of Advanced Biomedical and Pharmaceutical Sciences, 6, 3, 2023, 114-123. doi: 10.21608/jabps.2023.198467.1183
Elshamsy, A., Ali, T., Osman, M., El-Koussi, N. (2023). 'Recent progress in biological activities of dihydropyrimidine derivatives: An updated mini-review', Journal of Advanced Biomedical and Pharmaceutical Sciences, 6(3), pp. 114-123. doi: 10.21608/jabps.2023.198467.1183
Elshamsy, A., Ali, T., Osman, M., El-Koussi, N. Recent progress in biological activities of dihydropyrimidine derivatives: An updated mini-review. Journal of Advanced Biomedical and Pharmaceutical Sciences, 2023; 6(3): 114-123. doi: 10.21608/jabps.2023.198467.1183
Recent progress in biological activities of dihydropyrimidine derivatives: An updated mini-review
1Medicinal Chemistry Department, Faculty of Pharmacy, Deraya University, Minia, Egypt
2Department of Medicinal chemistry, Faculty of pharmacy, Minia university, Minia, Egypt
3Medicinal Chemistry Department, Faculty of Pharmacy, Minia University.
4Medicinal Chemistry Department, Faculty of Pharmacy, Deraya University, Minia, Egypt; Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Abstract
Dihydropyrimidines (DHPMs) are a class of nitrogen-containing heterocycles that have attracted considerable interest due to their great significance in organic and medicinal chemistry. In recent years, many biologically active molecules featuring DHPM moiety have been synthesized and biologically evaluated, some of which have served as potential leads for critical unmet pathological conditions such as the antimitotic Monastrol and the antiviral GLS4, which entered clinical trials a few years ago. This review discusses briefly the recent advances in DHPM-based bioactive compounds, their biological activities, and their mechanisms of action, which could provide references for future developments of more potent and selective leads.
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