Recent progress in biological activities of dihydropyrimidine derivatives: An updated mini-review

Elshamsy, Ali M.; Ali, Taha F. S.; Osman, Mohamed; El-Koussi, Nawal A.

doi:10.21608/jabps.2023.198467.1183

Recent progress in biological activities of dihydropyrimidine derivatives: An updated mini-review

Document Type : Review Articles

Authors

¹ Medicinal Chemistry Department, Faculty of Pharmacy, Deraya University, Minia, Egypt

² Department of Medicinal chemistry, Faculty of pharmacy, Minia university, Minia, Egypt

³ Medicinal Chemistry Department, Faculty of Pharmacy, Minia University.

⁴ Medicinal Chemistry Department, Faculty of Pharmacy, Deraya University, Minia, Egypt; Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

10.21608/jabps.2023.198467.1183

Abstract

Dihydropyrimidines (DHPMs) are a class of nitrogen-containing heterocycles that have attracted considerable interest due to their great significance in organic and medicinal chemistry. In recent years, many biologically active molecules featuring DHPM moiety have been synthesized and biologically evaluated, some of which have served as potential leads for critical unmet pathological conditions such as the antimitotic Monastrol and the antiviral GLS4, which entered clinical trials a few years ago. This review discusses briefly the recent advances in DHPM-based bioactive compounds, their biological activities, and their mechanisms of action, which could provide references for future developments of more potent and selective leads.

Keywords