Home Articles List Article Information
Journal of Advanced Biomedical and Pharmaceutical Sciences
Journal Archive
Volume Volume 8 (2025)
Volume Volume 7 (2024)
Volume Volume 6 (2023)
Volume Volume 5 (2022)
Volume Volume 4 (2021)
Volume Volume 3 (2020)
Volume Volume 2 (2019)
Volume Volume 1 (2018)
Ahmed, A., sameh, S., el-daly, M. (2025). Potential Role of Fibroblast Growth Factors (FGFs) in Benign Prostatic Hyperplasia. Journal of Advanced Biomedical and Pharmaceutical Sciences, 8(2), 7-11. doi: 10.21608/jabps.2025.361344.1231
Asmaa Ahmed; sarah sameh; Mahmoud el-daly. "Potential Role of Fibroblast Growth Factors (FGFs) in Benign Prostatic Hyperplasia". Journal of Advanced Biomedical and Pharmaceutical Sciences, 8, 2, 2025, 7-11. doi: 10.21608/jabps.2025.361344.1231
Ahmed, A., sameh, S., el-daly, M. (2025). 'Potential Role of Fibroblast Growth Factors (FGFs) in Benign Prostatic Hyperplasia', Journal of Advanced Biomedical and Pharmaceutical Sciences, 8(2), pp. 7-11. doi: 10.21608/jabps.2025.361344.1231
Ahmed, A., sameh, S., el-daly, M. Potential Role of Fibroblast Growth Factors (FGFs) in Benign Prostatic Hyperplasia. Journal of Advanced Biomedical and Pharmaceutical Sciences, 2025; 8(2): 7-11. doi: 10.21608/jabps.2025.361344.1231

Potential Role of Fibroblast Growth Factors (FGFs) in Benign Prostatic Hyperplasia

Article 1, Volume 8, Issue 2, April 2025, Page 7-11  XML PDF (486.88 K)
Document Type: Review Articles
DOI: 10.21608/jabps.2025.361344.1231
View on SCiNiTO View on SCiNiTO
Authors
Asmaa Ahmed email 1; sarah sameh2; Mahmoud el-daly2
1Department of pharmacology and toxicology, Faculty of pharmacy, minia
2Department of pharmacology and toxicology, faculty of pharmacy, minia university
Abstract
Benign prostatic hyperplasia (BPH) is a nonmalignant overgrowth of the prostate gland that is associated with lower urinary tract symptoms which deteriorate the patient's quality of life. Despite the high prevalence of BPH among aged men, its pathophysiology is not completely understood. Both androgenic and non-androgenic factors mediate the pathophysiology of prostatic hyperplasia. However, inflammation plays a crucial role in BPH pathophysiology. The inflammatory injury stimulates the production of variant cytokines and local growth factors that induce tissue remodeling and stromal hyperproliferation. Fibroblast growth factors (FGFs) are the most versatile in their ability to regulate cellular proliferation and differentiation. In this review, we will discuss the evidence that supports the role of FGFs in BPH and their signaling pathways involved in stromal hyperplasia.
Keywords
BPH; Inflammation; FGF-2; FGF-7; FGF-9
Main Subjects
Pharmacology and Toxicology
Statistics
Article View: 208
PDF Download: 176