Formulation And Evaluation Of Buccoadhesive Films of Lidocaine Hydrochloride

Document Type : Original Article

Authors

1 Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia

2 Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University 71526, Assiut, Egypt

3 Department of Pharmaceutics, Faculty of Pharmacy, Assiut University 71526, Assiut, Egypt

Abstract

Buccal delivery is considered the most suitable, easy, and safest route of administration. So it can be used as an alternative route to the peroral route for the systemic administration of drugs. Oral films (OFs) are used as a unique approach, because it dissolves quickly in the mouth and directly reaches to the systemic circulation. The aim of this study is to formulate and evaluate OF of an anaethetic drug lidocaine (LH) and improve its local effect. Oral films were prepared by using chitosan and polyvinylpyrolidone. OFs were assessed for compatibility studies, surface pH, swelling properties, In-Vitro bioadhesion, mechanical properties, disintegration time, dissolution time and in- vitro drug release. It was found that actual LH content in the prepared patch was in the range of 95-105% of the claimed content. The addition of propylene glycol as a plasticizer gave good mechanical properties in concentration of 40%. The prepared oral films swelled and reached an Equilibrium state of swelling. The prepared polymeric films showed good adhesion and acceptable pH. It could be concluded that the release of LH is higher from films contain 1% chitosan. Increasing chitosan concentration to 2% resulted in decreasing the initial dissolution rate. The combination of chitosan (2%) , PVP(10%) and PG at 40% w/w gave a reasonable LH release.

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