Document Type : Review Articles
Authors
1
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Menoufia University Menoufia, Egypt
2
Associate professor at Medicinal chemistry department Minia university
3
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Menoufia University, Menoufia, Egypt.
4
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524 Sohag, Egypt
5
Department of Biochemistry, Faculty of Pharmacy, Menoufia University, Menoufia, Egypt
6
Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, New Minia, Minia, Egypt.
Abstract
Pyridines have occupied a unique place in medicinal chemistry as it is widely profound as natural products and formed the integral backbone of great number of drugs in the market. In particular, 3-cyano-2-oxa-pyridines showed diverse biological and pharmacological activities such as cardiotonic, antimicrobial, antidepressant, and anticancer activity. 3-Cyano-2-oxa-pyridine derivatives have elevated importance for modern medicinal applications especially in cancer therapy. This article shed light on the general chemical synthetic approaches of 3-cyano-2-oxa-pyridines and summarized their various biological activities and pharmacological uses. This article may be helpful in the future to direct attention towards utilization of 3-cyano-2-oxa-pyridine template in the design of new molecules with enhanced biological properties such as PIM1 kinase, tubulin polymerase and survivin inhibitors for cancer therapy or new AMPK activator for diabetes and obesity control or cardiotonic agents.
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