Allam, K., Khedr, A., Allam, A., Abdelkader, M., Elkhayat, E., Fouad, M. (2021). Chemical and Biological Diversity in Nephthea Soft Corals in the Current Decade: A Review. Journal of Advanced Biomedical and Pharmaceutical Sciences, 4(3), 124-133. doi: 10.21608/jabps.2021.62966.1121
Khaled M. Allam; Amgad I.M. Khedr; Ahmed E. Allam; Mohamed Salaheldin A. Abdelkader; Ehab S. Elkhayat; Mostafa A. Fouad. "Chemical and Biological Diversity in Nephthea Soft Corals in the Current Decade: A Review". Journal of Advanced Biomedical and Pharmaceutical Sciences, 4, 3, 2021, 124-133. doi: 10.21608/jabps.2021.62966.1121
Allam, K., Khedr, A., Allam, A., Abdelkader, M., Elkhayat, E., Fouad, M. (2021). 'Chemical and Biological Diversity in Nephthea Soft Corals in the Current Decade: A Review', Journal of Advanced Biomedical and Pharmaceutical Sciences, 4(3), pp. 124-133. doi: 10.21608/jabps.2021.62966.1121
Allam, K., Khedr, A., Allam, A., Abdelkader, M., Elkhayat, E., Fouad, M. Chemical and Biological Diversity in Nephthea Soft Corals in the Current Decade: A Review. Journal of Advanced Biomedical and Pharmaceutical Sciences, 2021; 4(3): 124-133. doi: 10.21608/jabps.2021.62966.1121
Chemical and Biological Diversity in Nephthea Soft Corals in the Current Decade: A Review
1Department of Pharmacognosy, Faculty of Pharmacy, South Valley University
2Department of Pharmacognosy, Faculty of Pharmacy, Port Said University, Port Said P.O. Box 42526 Egypt. Faculty of Pharmacy, Horus University-Egypt, New Damietta, P.O. Box 34518 Egypt.
3Pharmacognosy Dept., Faculty of Pharmacy, Al-Azhar University, Assiut Branch.
4Department of Pharmacognosy, Faculty of Pharmacy, Sohag University, Nasr City, Eastern Avenue, P.O. Box 11432, Sohag, Egypt.
5Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut P.O. Box 71524, Egypt.
6Department of Pharmacognosy, Faculty of Pharmacy, Minia University, P.O. Box 61519 Minia, Egypt.
Abstract
Marine natural products play an important role within the innovation of lead compounds for drug development. The soft coral genus Nephthea has proven to be a treasurable source to discover new natural products with biological potentials. This review provides a survey of all metabolites isolated from the genus Nephthea in the current decade, along with their natural sources, chemical structures and biological potentials whenever possible. The current review aimed to compare chemical and biological diversity in the soft corals genus Nephthea. We listed 54 compounds including steroids and diterpenes. The steroids are the most abundant compounds of the genus Nephthea (74 %) followed by diterpenes (20%) and miscellaneous compounds (6%). The isolated compounds from genus Nephthea in the current decade have been shown different biological activities as cytotoxic against different cancer cell lines (29 compounds), as anti-inflammatory (13 compounds), antifouling (3 compounds) and antibacterial (2 compounds).
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