Ahmed, S., Fahim, J., Abdelmohsen, U. (2022). Chemical and biological studies on Allium sativum L. (1952-2020): A comprehensive review. Journal of Advanced Biomedical and Pharmaceutical Sciences, 5(1), 1-22. doi: 10.21608/jabps.2021.90667.1137
Shereen Sayed Taha Ahmed; John Refaat Fahim; Usama Ramadan Abdelmohsen. "Chemical and biological studies on Allium sativum L. (1952-2020): A comprehensive review". Journal of Advanced Biomedical and Pharmaceutical Sciences, 5, 1, 2022, 1-22. doi: 10.21608/jabps.2021.90667.1137
Ahmed, S., Fahim, J., Abdelmohsen, U. (2022). 'Chemical and biological studies on Allium sativum L. (1952-2020): A comprehensive review', Journal of Advanced Biomedical and Pharmaceutical Sciences, 5(1), pp. 1-22. doi: 10.21608/jabps.2021.90667.1137
Ahmed, S., Fahim, J., Abdelmohsen, U. Chemical and biological studies on Allium sativum L. (1952-2020): A comprehensive review. Journal of Advanced Biomedical and Pharmaceutical Sciences, 2022; 5(1): 1-22. doi: 10.21608/jabps.2021.90667.1137
Chemical and biological studies on Allium sativum L. (1952-2020): A comprehensive review
1Department of pharmacognosy, faculty of pharmacy, Minia university
2Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
3Department of Pharmacognosy, faculty of Pharmacy, Minia University, 61519 Minia, Egypt
Abstract
Medicinal plants provide a variety of secondary metabolites with varied chemical structures and biological activities. Among them, Allium sativum L. (garlic) is one of the most common edible and traditional plant that is used for the prevention and treatment of several diseases. A. sativum belongs to the family Liliaceae and it demonstrated diverse groups of natural compounds (185 compounds), such as organosulfur compounds, amino acids, selenium derivatives, saponins, phenyl propanoids, flavonoids, alkaloids, fatty acids, sterols and others. Therefore, this review focuses on the different classes of secondary metabolites that have been isolated from A. sativum, along with their valued pharmacological and therapeutic effects, e.g., anti-infective (antiprotozoal, antibacterial, antifungal and antiviral activities), antidiabetic, antihyperlipidemic, antihypertensive, heart protective, neuroprotective, hepatoprotective, antioxidant, anticancer, antiobesity, wound and scar healing, antianxiety, antidepressant, immunostimulant and memory enhancing properties. The potential of garlic in the treatment of many diseases such as gastrointestinal disorders, nephropathic encephalopathy and osteoarthritis has been also reported.
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