Fahim, J., Ahmed, S., Abdelmohsen, U., Hamed, A. (2023). Anti-HCV potential of the medicinal roots of khella and celery plants. Journal of Advanced Biomedical and Pharmaceutical Sciences, 6(3), 145-149. doi: 10.21608/jabps.2023.201852.1186
John Refaat Fahim; Shereen Sayed Taha Ahmed; Usama Ramadan Abdelmohsen; Ashraf Hamed. "Anti-HCV potential of the medicinal roots of khella and celery plants". Journal of Advanced Biomedical and Pharmaceutical Sciences, 6, 3, 2023, 145-149. doi: 10.21608/jabps.2023.201852.1186
Fahim, J., Ahmed, S., Abdelmohsen, U., Hamed, A. (2023). 'Anti-HCV potential of the medicinal roots of khella and celery plants', Journal of Advanced Biomedical and Pharmaceutical Sciences, 6(3), pp. 145-149. doi: 10.21608/jabps.2023.201852.1186
Fahim, J., Ahmed, S., Abdelmohsen, U., Hamed, A. Anti-HCV potential of the medicinal roots of khella and celery plants. Journal of Advanced Biomedical and Pharmaceutical Sciences, 2023; 6(3): 145-149. doi: 10.21608/jabps.2023.201852.1186
Anti-HCV potential of the medicinal roots of khella and celery plants
1Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
2Department of pharmacognosy, faculty of pharmacy, Minia university
3Department of Pharmacognosy, faculty of Pharmacy, Minia University, 61519 Minia, Egypt
Abstract
Khella (Ammi visnaga (L.) Lam.) and celery (Apium graveolens L.) are two valuable medicinal plant species with a wide-ranging health and therapeutic benefits, including hepatoprotective and antiviral properties. Thus, in this work, the total ethanolic extracts of the roots of the aforementioned species were studied for their antiviral potential against Hepatitis C virus (HCV) using the in vitro luciferase assay. The obtained data demonstrated the noteworthy inhibitory activity of khella roots against HCV (IC50= 9.5 µg/ml), while no noticeable inhibition was shown by celery roots. Besides, three phytosterols (I‒III) and one furanochromone (IV), with previously reported antiviral properties, were isolated and identified from khella roots for the first time. These data could pave the way towards further phytochemical and biological investigation of such medicinal roots as potential sources of natural anti-HCV agents.
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