Thabit, K., Bkeet, A., Abdelhalem, E., Sharaf, A., Eltahir, H., Abouzied, M., Ahmed, A. (2023). Single nucleotide polymorphisms in INFL3-INFL4 region are associated with fibrosis and cirrhosis in Egyptian patients with chronic hepatitis C. Journal of advanced Biomedical and Pharmaceutical Sciences, 6(4), 228-233. doi: 10.21608/jabps.2023.233765.1199
Khalid Thabit; Amany Bkeet; Elham Abdelhalem; Abeer Sharaf; Heba Eltahir; Meky M Abouzied; Abo Bakr F Ahmed. "Single nucleotide polymorphisms in INFL3-INFL4 region are associated with fibrosis and cirrhosis in Egyptian patients with chronic hepatitis C". Journal of advanced Biomedical and Pharmaceutical Sciences, 6, 4, 2023, 228-233. doi: 10.21608/jabps.2023.233765.1199
Thabit, K., Bkeet, A., Abdelhalem, E., Sharaf, A., Eltahir, H., Abouzied, M., Ahmed, A. (2023). 'Single nucleotide polymorphisms in INFL3-INFL4 region are associated with fibrosis and cirrhosis in Egyptian patients with chronic hepatitis C', Journal of advanced Biomedical and Pharmaceutical Sciences, 6(4), pp. 228-233. doi: 10.21608/jabps.2023.233765.1199
Thabit, K., Bkeet, A., Abdelhalem, E., Sharaf, A., Eltahir, H., Abouzied, M., Ahmed, A. Single nucleotide polymorphisms in INFL3-INFL4 region are associated with fibrosis and cirrhosis in Egyptian patients with chronic hepatitis C. Journal of advanced Biomedical and Pharmaceutical Sciences, 2023; 6(4): 228-233. doi: 10.21608/jabps.2023.233765.1199
Single nucleotide polymorphisms in INFL3-INFL4 region are associated with fibrosis and cirrhosis in Egyptian patients with chronic hepatitis C
1Department of biochemistry, faculty of Pharmacy, Minia University, Minia, Egypt
2Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia, Egypt
3Department of Gastroenterology and Tropical Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt
4Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al-Madinah Almunawwarah, Kingdom of Saudi Arabia
5Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Madinah, Saudi Arabia.
6Microbiology and Immunology department, Faculty of Pharmacy, Minia University, Minia, Egypt
Abstract
Genetic variables have a notable and polygenic impact on the incidence and development of hepatic fibrosis and cirrhosis in individuals with chronic hepatitis C (CHC). Genetic polymorphisms in interferon-λ3-interferon- λ4 (INFL3-INFL4) region, rs12979860 and its highly linked disequilibrium polymorphisms (rs368234815 and rs4803217) are linked to liver inflammation and fibrosis progression in CHC individuals from different ethnic groups. For Egyptian patients, no data available about the degree of linkage disequilibrium between these variants and their effect on liver fibrosis. In this study, 99 healthy controls and 176 CHC patients were genotyped for 3 variants in (INFL3-INFL4) region rs12979860, rs4803217, and rs368234815. We found that these variants are highly linked disequilibrium in Egyptian CHC cohort. Moreover, we found that the major alleles of these 3 polymorphisms (rs12979860, rs4803217, and rs368234815) significantly increase the risk of liver fibrosis (P = 0.015, 0.026, and 0.007 respectively). Additionally, these variants were linked to stage of hepatic fibrosis. This report shows that the 3 linked disequilibrium variants in INFL3-INFL4 region may be valuable foretellers of liver fibrosis and cirrhosis in CHC Egyptian patients.
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