The Role of 3D Bioprinting in Drug Discovery: A review

Document Type : Review Articles

Authors

1 Third World Center for Science and Technology, HEJ research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270 Pakistan

2 Department of biochemistry Government College University Faisalabad, Faisalabad Pakistan

Abstract

The emerging area of 3D bioprinting is enhanced rapidly. The 3D bioprinting idea was formulated in the 1970s since this technology has been used extensively. In this technology, a digital file is used to produce a living organ-like structure in three dimensions. Being extensively used in tissue regeneration, medical devices, sensors, tissue scaffolds, etc. it plays a major role in drug design. In the last few decades, drug discovery in its traditional ways spans along with huge cost. These earlier techniques like high-throughput screening, computer-aided drug designing, and fragment-based designing, etc. have various limitations. Meanwhile, the 3D bioprinting technology offers the advantages of fastness, ease, and cost-effectiveness. Several reviews and experimental data are available that cover the application of 3D bioprinting in various industries, but comprehensive literature focusing on the role of 3D bioprinting in the drug was scarce. Hence, this review aimed to document the role of 3D bioprinting in drug discovery, methods of 3D bioprinting, and exploit 3D bioprinting technology in the drug development and discovery process. The critically evaluated literature shows the positive usage of 3D bioprinting technology in the development of drug discovery and provides benefits i.e. fast nature, low cost, and ease handling.

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