Eltahir, H., Maher, S., Elrihany, M., Mohamed, H., wahid, A., Alamri, A., Al thagfan, S., Abouzied, M., Shalkami, A., Fawzy, M. (2024). The association between the survivin gene -31G/C polymorphism and risk of hepatocellular carcinoma in Egyptian population.. Journal of Advanced Biomedical and Pharmaceutical Sciences, 7(3), 103-108. doi: 10.21608/jabps.2024.278357.1217
Heba Eltahir; Sherif Ali Maher; Mahmoud Elrihany; Hala Ibrahim Mohamed; Ahmed wahid; Amer A Alamri; Sultan Al thagfan; Meky M Abouzied; Abdel-Gawad S Shalkami; Michael A Fawzy. "The association between the survivin gene -31G/C polymorphism and risk of hepatocellular carcinoma in Egyptian population.". Journal of Advanced Biomedical and Pharmaceutical Sciences, 7, 3, 2024, 103-108. doi: 10.21608/jabps.2024.278357.1217
Eltahir, H., Maher, S., Elrihany, M., Mohamed, H., wahid, A., Alamri, A., Al thagfan, S., Abouzied, M., Shalkami, A., Fawzy, M. (2024). 'The association between the survivin gene -31G/C polymorphism and risk of hepatocellular carcinoma in Egyptian population.', Journal of Advanced Biomedical and Pharmaceutical Sciences, 7(3), pp. 103-108. doi: 10.21608/jabps.2024.278357.1217
Eltahir, H., Maher, S., Elrihany, M., Mohamed, H., wahid, A., Alamri, A., Al thagfan, S., Abouzied, M., Shalkami, A., Fawzy, M. The association between the survivin gene -31G/C polymorphism and risk of hepatocellular carcinoma in Egyptian population.. Journal of Advanced Biomedical and Pharmaceutical Sciences, 2024; 7(3): 103-108. doi: 10.21608/jabps.2024.278357.1217
The association between the survivin gene -31G/C polymorphism and risk of hepatocellular carcinoma in Egyptian population.
1Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al-Madinah Almunawwarah, Kingdom of Saudi Arabia
2Department of Biochemistry, Faculty of pharmacy, New valley University, New Valley, El-kharga city 71511, Egypt
3Department of Biochemistry, Faculty of pharmacy, Deraya University, New Minia city 61111, Egypt
4Department of hepatology and gastroenterology, Faculty of medicine, Minia University, Minia city 61519, Egypt
5Department of Biochemistry, Faculty of pharmacy, Alexindria University, Egypt
6Medical center Taibah University, Medina, Kingdom of Saudi Arabia
7Department of clinical and hospital pharmacy, College of Pharmacy, Taibah University, Medina, Kingdom of Saudi Arabia
8Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Madinah, Saudi Arabia.
9Clinical Pharmacy program, Al-Rayan Colleges, Medina, Kingdom of Saudi Arabia
10Department of faculty of Pharmacy, Minia University, Minia, Egypt
Abstract
Background: Survivin is one of the most crucial apoptosis inhibitory genes, playing a basic role in hepatocellular carcinoma (HCC) development and progression. The current study aims at investigating the relationship of survivin polymorphism with the risk of HCC in Hepatitis C virus-infected Egyptian population. Methods: the study was conducted on 120 Egyptian individuals divided into: healthy controls, fibrotic patients, cirrhotic patients and HCC patients (30 subjects/group). History and risk factors were collected and recorded for all cases. Polymorphism of the survivin gene, including one locus (rs9904341) was chosen for genotyping using (PCR-RFLP) technique. Results: No statistically significant difference was detected in the genotype or allele distribution of HCC subjects in respect to the controls (P>0.05). On the other hand, a significant difference could be detected in genotype or allele distribution in fibrosis and cirrhosis HCV patient groups compared to healthy controls (P<0.05). A significant difference in genotype or allele distribution was detected in HCC group compared to cirrhosis group (P<0.05). No statistically significant difference was found in genotype or allele distribution of fibrosis cases relative to the controls. Conclusion: No relationship between Survivin gene (-31G/C) polymorphism rs9904341 and the risk of HCC could be found in HCV-infected Egyptian population. However, a positive correlation could be detected between Survivin gene polymorphism and the risk of cirrhosis in the same population. The study also identified a relationship between survivin gene polymorphism in cirrhosis relative to fibrosis as well as between survivin gene (–31G/C) polymorphism rs9904341 in HCC relative to cirrhosis.
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