The antiinflammatory activity and LD50 of Ocimum forskolei Benth., family Lamiaceae

Zahran, Eman Maher; Khalil, Hany Ezzat; Desoukey, Samar Yehia; Fouad, Mostafa Ahmed; Kamel, Mohamed Salah

doi:10.21608/jabps.2019.12973.1048

The antiinflammatory activity and LD50 of Ocimum forskolei Benth., family Lamiaceae

Document Type : Short Communication.

Authors

¹ Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, 61111 New Minia, Egypt

² Department of Pharmaceutical Sciences, Faculty of Clinical Pharmacy, King Faisal University, 31982 Al-Ahsa, Saudi Arabia

³ Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

10.21608/jabps.2019.12973.1048

Abstract

The present study aimed to determine the lethal dose {LD50} using acute toxicity models and evaluate the anti-inflammatory activity of the total ethanolic extract (TEE) and different fractions of Ocimum forskolei Benth. aerial parts (leaves and stems) following the carrageenan-induced paw edema model in rats. The results obtained revealed that the LD50 value of the TEE was 8 g/kg body weight, while the extract and different fractions showed a significant decrease in paw edema, especially the aqueous fraction treated group with a % inhibition of (40.77 %, P < 0.001) in comparison with indomethacin (55.55 %, P < 0.001) as a standard.

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