Zahran, E., khalil, H., Desoukey, S., Fouad, M., Kamel, M. (2019). The antiinflammatory activity and LD50 of Ocimum forskolei Benth., family Lamiaceae. Journal of Advanced Biomedical and Pharmaceutical Sciences, 2(3), 116-120. doi: 10.21608/jabps.2019.12973.1048
Eman Maher Zahran; Hany Ezzat khalil; Samar Yehia Desoukey; Mostafa Ahmed Fouad; Mohamed Salah Kamel. "The antiinflammatory activity and LD50 of Ocimum forskolei Benth., family Lamiaceae". Journal of Advanced Biomedical and Pharmaceutical Sciences, 2, 3, 2019, 116-120. doi: 10.21608/jabps.2019.12973.1048
Zahran, E., khalil, H., Desoukey, S., Fouad, M., Kamel, M. (2019). 'The antiinflammatory activity and LD50 of Ocimum forskolei Benth., family Lamiaceae', Journal of Advanced Biomedical and Pharmaceutical Sciences, 2(3), pp. 116-120. doi: 10.21608/jabps.2019.12973.1048
Zahran, E., khalil, H., Desoukey, S., Fouad, M., Kamel, M. The antiinflammatory activity and LD50 of Ocimum forskolei Benth., family Lamiaceae. Journal of Advanced Biomedical and Pharmaceutical Sciences, 2019; 2(3): 116-120. doi: 10.21608/jabps.2019.12973.1048
The antiinflammatory activity and LD50 of Ocimum forskolei Benth., family Lamiaceae
1Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, 61111 New Minia, Egypt
2Department of Pharmaceutical Sciences, Faculty of Clinical Pharmacy, King Faisal University, 31982 Al-Ahsa, Saudi Arabia
3Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
Abstract
The present study aimed to determine the lethal dose {LD50} using acute toxicity models and evaluate the anti-inflammatory activity of the total ethanolic extract (TEE) and different fractions of Ocimum forskolei Benth. aerial parts (leaves and stems) following the carrageenan-induced paw edema model in rats. The results obtained revealed that the LD50 value of the TEE was 8 g/kg body weight, while the extract and different fractions showed a significant decrease in paw edema, especially the aqueous fraction treated group with a % inhibition of (40.77 %, P < 0.001) in comparison with indomethacin (55.55 %, P < 0.001) as a standard.
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