Current Trends and Future Perspectives of Hydrogen Sulfide Donors

Document Type : Review Articles

Authors

1 Medicinal Chemistry Department, Faculty of Pharmacy, Minia University.

2 Associate professor at Medicinal chemistry department Minia university

3 Medicinal Chemistry Department, Faculty of Pharmacy, Minia University

Abstract

ABSTRACT:
Hydrogen sulfide (H2S) gas is included to be the most critical endogenous gasotransmitters that has several pathophysiological effects in many human cells and organ tissues. The synthesis of endogenous H2S in cells via several pathways. Variant biological effects of H2S including ion channel regulation, redox regulation of protein, thiols, polysulfides, thiosulfate/sulfite, and anti-oxidant activities affecting many cellular and molecular reactions. Therefore, it is essential to review H2S chemical biology, methods of detection of H2S release and its effects on pathological and physiological functions along with their therapeutic uses, including cardiovascular protective activities, anti-inflammatory and anti-tumor activities of the H2S donors.

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Journal of Advanced Biomedical and Pharmaceutical Sciences
Volume 4, Issue 4
October 2021
Pages 231-245

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