Bayoumi, A., Khalifa, E., Sayed-Ahmed, M., Sharaky, M., Nazmy, M. (2024). Resveratrol inhibits epithelial-mesenchymal transition in hepatocellular carcinoma. Journal of Advanced Biomedical and Pharmaceutical Sciences, 7(1), 37-40. doi: 10.21608/jabps.2023.233421.1201
Asmaa Bayoumi; Esraa Khalifa; Mohamed M. Sayed-Ahmed; Marwa Sharaky; Maiiada H. Nazmy. "Resveratrol inhibits epithelial-mesenchymal transition in hepatocellular carcinoma". Journal of Advanced Biomedical and Pharmaceutical Sciences, 7, 1, 2024, 37-40. doi: 10.21608/jabps.2023.233421.1201
Bayoumi, A., Khalifa, E., Sayed-Ahmed, M., Sharaky, M., Nazmy, M. (2024). 'Resveratrol inhibits epithelial-mesenchymal transition in hepatocellular carcinoma', Journal of Advanced Biomedical and Pharmaceutical Sciences, 7(1), pp. 37-40. doi: 10.21608/jabps.2023.233421.1201
Bayoumi, A., Khalifa, E., Sayed-Ahmed, M., Sharaky, M., Nazmy, M. Resveratrol inhibits epithelial-mesenchymal transition in hepatocellular carcinoma. Journal of Advanced Biomedical and Pharmaceutical Sciences, 2024; 7(1): 37-40. doi: 10.21608/jabps.2023.233421.1201
Resveratrol inhibits epithelial-mesenchymal transition in hepatocellular carcinoma
1Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
2Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
3Pharmacology and Experimental Oncology Unit, National Cancer Institute, Cairo University, Cairo 11796, Egypt.
4Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Abstract
Hepatocellular carcinoma (HCC) is a brutally aggressive cancer that puts a tremendous amount of strain on both the medical systems and the drug regulatory organizations as well. It is believed that a crucial stage in the development of HCC is the epithelial-mesenchymal transition (EMT), which increases hepatocyte malignancy and is linked to invasion and metastasis. Resveratrol (RES) has been shown to reverse EMT in a number of cancer types. In order to further understand how RES influences EMT in HCC, we have chosen to concentrate on studying and summarizing the serine/threonine kinase (Akt)/glycogen synthesis kinase 3-beta (GSK3β)/Snail signaling pathway as one of the central pathways involved in activating EMT and tumorigenesis in this review.
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